Randomized trial of doxycycline versus josamycin for Mediterranean spotted fever

Antimicrob Agents Chemother. 1990 May;34(5):937-8. doi: 10.1128/AAC.34.5.937.

Abstract

We undertook a randomized clinical trial comparing therapeutic efficacy of the 1-day doxycycline regimen with the 5-day josamycin regimen for Mediterranean spotted fever. All 59 patients recovered uneventfully, and results did not significantly differ between the two schedules. One-day doxycycline therapy is an effective, easy, and inexpensive treatment. Josamycin is a useful therapeutic alternative that may be particularly convenient for pregnant women and patients with a history of allergy to tetracyclines.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Child
  • Child, Preschool
  • Doxycycline / therapeutic use*
  • Female
  • Humans
  • Josamycin / therapeutic use*
  • Male
  • Middle Aged
  • Randomized Controlled Trials as Topic
  • Rickettsia Infections / drug therapy*

Substances

  • Josamycin
  • Doxycycline