Active and passive immunization against Acinetobacter baumannii using an inactivated whole cell vaccine

Vaccine. 2010 Dec 10;29(1):1-5. doi: 10.1016/j.vaccine.2010.10.052. Epub 2010 Nov 18.

Abstract

The treatment of infections caused by Acinetobacter baumannii has become increasingly complicated due to the emergence of highly resistant strains. In the present study we demonstrate that immunization with an inactivated whole cell vaccine elicits a robust antibody response that provides protection against challenge with multiple A. baumannii strains in a murine model of disseminated sepsis. In addition, we show that passive immunization with serum raised against inactivated cells protects mice from subsequent infection. These results demonstrate that active and passive immunization using an inactivated whole cell vaccine may be an effective approach for preventing infection by A. baumannii.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acinetobacter Infections / prevention & control*
  • Acinetobacter baumannii / immunology*
  • Animals
  • Bacterial Vaccines / administration & dosage
  • Bacterial Vaccines / immunology*
  • Disease Models, Animal
  • Female
  • Immune Sera / administration & dosage
  • Immune Sera / immunology
  • Immunization, Passive / methods*
  • Mice
  • Mice, Inbred C57BL
  • Sepsis / prevention & control
  • Vaccination / methods*
  • Vaccines, Inactivated / administration & dosage
  • Vaccines, Inactivated / immunology

Substances

  • Bacterial Vaccines
  • Immune Sera
  • Vaccines, Inactivated