In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to seven fluoroquinolones

Antimicrob Agents Chemother. 1990 Nov;34(11):2287-8. doi: 10.1128/AAC.34.11.2287.

Abstract

The in vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to seven fluoroquinolones were assessed by the agar dilution method. Ciprofloxacin and temafloxacin were the most active compounds (MIC for 90% of isolates tested [MIC90], 0.06 microgram/ml), while enoxacin and pefloxacin were the least active (MIC90, 0.5 microgram/ml). Fleroxacin, lomefloxacin, and ofloxacin showed intermediate activities (MIC90s, 0.125 to 0.25 microgram/ml). These results suggest a possible role for the fluoroquinolones in the treatment of pertussis, at least in adult patients.

Publication types

  • Comparative Study

MeSH terms

  • 4-Quinolones
  • Anti-Infective Agents / pharmacology*
  • Bordetella / drug effects*
  • Bordetella pertussis / drug effects*
  • Humans
  • Microbial Sensitivity Tests
  • Whooping Cough / microbiology

Substances

  • 4-Quinolones
  • Anti-Infective Agents