Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France

Antimicrob Agents Chemother. 2010 Jun;54(6):2728-31. doi: 10.1128/AAC.01557-09. Epub 2010 Apr 12.

Abstract

Susceptibility to antibiotics of 4,816 clinical L. monocytogenes strains isolated since 1926 was studied, and the temporal evolution of susceptibility to antibiotics was analyzed through several decades. The mechanisms of resistance in each resistant strain were studied. The prevalence of resistant strains was estimated at 1.27% among isolates from humans. Resistance to tetracyclines+ and fluoroquinolones was more common and has recently emerged. Although acquired resistance in clinical L. monocytogenes did not implicate clinically relevant antibiotics, the possibility of resistance gene transfers, the description of the first clinical isolate with high-level resistance to trimethoprim, and the recent increase in penicillin MICs up to 2 microg/ml reinforce the need for microbiological surveillance.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Base Sequence
  • DNA Primers / genetics
  • Drug Resistance, Bacterial / genetics*
  • Evolution, Molecular
  • France / epidemiology
  • Gene Transfer, Horizontal
  • History, 20th Century
  • History, 21st Century
  • Humans
  • In Vitro Techniques
  • Listeria monocytogenes / drug effects*
  • Listeria monocytogenes / genetics*
  • Listeria monocytogenes / isolation & purification
  • Listeriosis / drug therapy*
  • Listeriosis / epidemiology
  • Listeriosis / history
  • Listeriosis / microbiology*
  • Microbial Sensitivity Tests
  • Molecular Epidemiology
  • Time Factors

Substances

  • Anti-Bacterial Agents
  • DNA Primers