Antiviral activity of ribavirin in rotavirus gastroenteritis of mice

Antimicrob Agents Chemother. 1977 Oct;12(4):543-4. doi: 10.1128/AAC.12.4.543.

Abstract

Ribavirin was inactive against the rotavirus of murine gastroenteritis; this may be due to the presence of guanosine inhibitors in the gut.

MeSH terms

  • Animals
  • Animals, Newborn
  • Gastroenteritis / drug therapy*
  • Mice
  • Mice, Inbred BALB C
  • Ribavirin / therapeutic use*
  • Ribonucleosides / therapeutic use*
  • Rotavirus
  • Virus Diseases / drug therapy*

Substances

  • Ribonucleosides
  • Ribavirin