Efficacy of different beta-lactams against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain in the rat intra-abdominal abscess model

L B Rice; J D Yao; K Klimm; G M Eliopoulos; R C Moellering Jr

doi:10.1128/AAC.35.6.1243

Efficacy of different beta-lactams against an extended-spectrum beta-lactamase-producing Klebsiella pneumoniae strain in the rat intra-abdominal abscess model

Antimicrob Agents Chemother. 1991 Jun;35(6):1243-4. doi: 10.1128/AAC.35.6.1243.

Authors

L B Rice¹, J D Yao, K Klimm, G M Eliopoulos, R C Moellering Jr

Affiliation

¹ Infectious Disease Section, New England Deaconess Hospital, Boston, Massachusetts.

Abstract

Although standard-inoculum MICs were within the susceptible range for all compounds, cefoperazone, cefotaxime, and cefpirome were significantly less effective than imipenem or the combination of cefoperazone and sulbactam in the treatment of rat intra-abdominal abscesses due to an extended-spectrum beta-lactamase-producing strain of Klebsiella pneumoniae.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Abdomen
Abscess / drug therapy*
Animals
Anti-Bacterial Agents / pharmacology*
Anti-Bacterial Agents / therapeutic use
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / enzymology
Microbial Sensitivity Tests
Rats
beta-Lactamases / metabolism*
beta-Lactams

Substances

Anti-Bacterial Agents
beta-Lactams
beta-Lactamases