Targeting virulence traits: potential strategies to combat extraintestinal pathogenic E. coli infections

Curr Opin Microbiol. 2008 Oct;11(5):409-13. doi: 10.1016/j.mib.2008.09.005. Epub 2008 Oct 14.

Abstract

Extraintestinal pathogenic Escherichia coli (ExPEC) are able to colonize, invade and induce disease in body niches outside the gastrointestinal tract. The emergence of (multi)resistant ExPEC variants calls for alternative antimicrobial strategies with a reduced pressure on selection of antibiotic resistances. We report on recent research efforts to target such virulence traits or to interfere with ExPEC colonization of extraintestinal niches in order to prevent or treat ExPEC infections and reduce the risk of further emergence of antibiotic resistances.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antibiosis
  • Drug Resistance, Bacterial
  • Escherichia coli / drug effects*
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / microbiology*
  • Escherichia coli Infections / prevention & control
  • Escherichia coli Proteins / antagonists & inhibitors*
  • Escherichia coli Vaccines / immunology
  • Humans
  • Virulence Factors / antagonists & inhibitors*

Substances

  • Escherichia coli Proteins
  • Escherichia coli Vaccines
  • Virulence Factors