Abstract
We previously found that caspofungin synergized with amphotericin B lipid complex in treating murine mucormycosis. We now report a similarly enhanced activity of liposomal amphotericin combined with micafungin or anidulafungin in mice with disseminated mucormycosis. The efficacy of combination echinocandin-polyene therapy for mucormycosis is a class effect.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphotericin B / administration & dosage
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Amphotericin B / therapeutic use
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Anidulafungin
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Animals
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Antifungal Agents* / administration & dosage
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Antifungal Agents* / therapeutic use
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Disease Models, Animal
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Drug Therapy, Combination
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Echinocandins* / administration & dosage
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Echinocandins* / therapeutic use
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Humans
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Lipopeptides
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Lipoproteins / administration & dosage
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Lipoproteins / therapeutic use
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Liposomes / administration & dosage
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Liposomes / therapeutic use
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Male
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Micafungin
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Mice
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Mice, Inbred BALB C
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Mucormycosis / drug therapy*
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Mucormycosis / microbiology
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Polyenes* / administration & dosage
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Polyenes* / therapeutic use
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Rhizopus / classification
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Rhizopus / drug effects*
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Treatment Outcome
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Lipoproteins
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Liposomes
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Polyenes
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Amphotericin B
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Anidulafungin
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Micafungin