Vancomycin-resistant enterococcal meningitis treated with intrathecal streptomycin

Panayiotis N Varelas; Mohammed Rehman; Wendy Pierce; Jody Wellwood; Thea Chua; Sanjay Revankar

doi:10.1016/j.clineuro.2007.11.005

Vancomycin-resistant enterococcal meningitis treated with intrathecal streptomycin

Clin Neurol Neurosurg. 2008 Apr;110(4):376-80. doi: 10.1016/j.clineuro.2007.11.005. Epub 2007 Dec 26.

Authors

Panayiotis N Varelas¹, Mohammed Rehman, Wendy Pierce, Jody Wellwood, Thea Chua, Sanjay Revankar

Affiliation

¹ Department of Neurology, Henry Ford Hospital, Detroit, MI 48202, United States. varelas@neuro.hfh.edu

PMID: 18162288
DOI: 10.1016/j.clineuro.2007.11.005

Abstract

Enterococcal meningitis is a rare complication of neurosurgical procedures. We present a patient who developed vancomycin-resistant enterococcal ventriculitis - meningitis after a brain tumor resection and ventriculoperitoneal shunt placement, treated successfully with intrathecal streptomycin through bilateral cerebrospinal fluid drainage catheters in addition to systemic antibiotics. This is the first report of such treatment for this resistant organism.

Publication types

Case Reports
Review

MeSH terms

Anti-Bacterial Agents / administration & dosage*
Brain Neoplasms / secondary*
Brain Neoplasms / surgery
Dose-Response Relationship, Drug
Drug Administration Schedule
Enterococcus faecalis* / drug effects
Frontal Lobe / surgery*
Gram-Positive Bacterial Infections / drug therapy*
Humans
Injections, Spinal
Male
Melanoma / secondary*
Melanoma / surgery
Meningitis, Bacterial / drug therapy*
Microsurgery
Middle Aged
Postoperative Complications / drug therapy*
Radiosurgery
Reoperation
Skin Neoplasms / surgery*
Streptomycin / administration & dosage*
Vancomycin Resistance*
Ventriculoperitoneal Shunt
Ventriculostomy

Substances

Anti-Bacterial Agents
Streptomycin