In vitro study of Candida tropicalis isolates exhibiting paradoxical growth in the presence of high concentrations of caspofungin

Antimicrob Agents Chemother. 2007 Dec;51(12):4474-6. doi: 10.1128/AAC.00880-07. Epub 2007 Oct 8.

Abstract

Paradoxical growth was noted in RPMI 1640 and antibiotic medium 3 in the case of 14 and 1 of 15 Candida tropicalis strains, respectively, at a caspofungin concentration of 12.5 microg/ml using minimum fungicidal concentration tests. Time-kill assays showed that against isolates killed at lower concentrations, caspofungin at a concentration of 12.5 microg/ml was only fungistatic.

MeSH terms

  • Antifungal Agents / pharmacology
  • Candida tropicalis / drug effects*
  • Candida tropicalis / growth & development
  • Caspofungin
  • Echinocandins / pharmacology*
  • Lipopeptides
  • Microbial Sensitivity Tests
  • Time Factors

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Caspofungin