Abstract
The long-term impact of Haemophilus influenzae type b (Hib) conjugate vaccine, introduced throughout Latin America in the late 1990s, has not been evaluated. Active surveillance for H. influenzae meningitis was performed from August 9, 1996 to August 8, 2004 in Metropolitan Salvador, Brazil. Five years after the introduction of Hib conjugate vaccine, Hib meningitis incidence decreased from 2.39 to 0.06 cases per 100,000 population (98%) overall, and from 60.9 to 3.1 cases per 100,000 population (95%) in children <1 year of age. A transient serotype replacement phenomenon was observed associated with a small increase of meningitis due to two H. influenzae type a clonal groups. These findings indicate that Hib immunization campaign has led to the virtual elimination of Hib disease in this region.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Brazil / epidemiology
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Child
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Child, Preschool
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Haemophilus Vaccines* / administration & dosage
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Haemophilus Vaccines* / immunology
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Haemophilus influenzae type b / classification
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Haemophilus influenzae type b / immunology*
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Haemophilus influenzae type b / isolation & purification
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Humans
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Immunization Programs*
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Incidence
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Infant
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Infant, Newborn
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Meningitis, Haemophilus / epidemiology*
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Meningitis, Haemophilus / microbiology
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Meningitis, Haemophilus / mortality
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Meningitis, Haemophilus / prevention & control
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Population Surveillance*
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Program Evaluation
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Serotyping
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Tetanus Toxoid* / administration & dosage
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Tetanus Toxoid* / immunology
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Vaccines, Conjugate* / administration & dosage
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Vaccines, Conjugate* / immunology
Substances
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Haemophilus Vaccines
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Haemophilus influenza type b polysaccharide vaccine-tetanus toxin conjugate
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Tetanus Toxoid
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Vaccines, Conjugate