Candida urinary tract infections: treatment options

Expert Rev Anti Infect Ther. 2007 Apr;5(2):277-84. doi: 10.1586/14787210.5.2.277.

Abstract

Candiduria is a nonspecific finding that occurs with contamination of a urine sample, colonization of an indwelling catheter and/or the bladder, symptomatic cystitis and invasive upper tract infection. Most patients are colonized and do not require antifungal therapy. Removing predisposing factors, such as indwelling catheters and antibiotics, will clear candiduria in almost 50% of asymptomatic patients. For patients with symptomatic Candida urinary tract infections, a variety of treatment options are available. Fluconazole is the antifungal agent of choice, achieving high urine concentrations with the oral formulation. Rarely, amphotericin B or flucytosine are used. Newer azole agents and echinocandins are not recommended for the treatment of urinary tract infections since they fail to achieve adequate urine concentrations.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Infective Agents, Urinary / administration & dosage
  • Anti-Infective Agents, Urinary / urine
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / urine
  • Candida / drug effects*
  • Candida / growth & development
  • Candidiasis / drug therapy*
  • Candidiasis / epidemiology
  • Candidiasis / microbiology
  • Contraindications
  • Humans
  • Urinary Tract Infections / drug therapy*
  • Urinary Tract Infections / epidemiology
  • Urinary Tract Infections / microbiology

Substances

  • Anti-Infective Agents, Urinary
  • Antifungal Agents