Outcome of hepatic amebic abscesses managed with three different therapeutic strategies

Dig Dis Sci. 1992 Feb;37(2):240-7. doi: 10.1007/BF01308178.

Abstract

Three different approaches to hepatic abscesses due to Entamoeba histolytica were compared in 51 patients. The three modes of therapy utilized were: medical therapy with nitroimidazoles (N = 11 patients), open surgical drainage (N = 9 patients), and percutaneous drainage using ultrasound guidance followed by intralesional nitroimidazole administration (N = 31 patients). The results with each form of therapy were assessed clinically and by abdominal ultrasound. Patients receiving combined US-guided drainage and intralesional chemotherapy experienced a faster and overall better clinical response, which was confirmed also by sonographic follow-up of the hepatic lesions. This better response was associated with faster resolution, fewer relapses, and less residual hepatic scarring than either with medical therapy alone or open surgical drainage combined with medical therapy.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Drainage / methods
  • Female
  • Humans
  • Injections, Intralesional
  • Liver Abscess, Amebic / complications
  • Liver Abscess, Amebic / diagnostic imaging
  • Liver Abscess, Amebic / pathology
  • Liver Abscess, Amebic / therapy*
  • Male
  • Middle Aged
  • Nitroimidazoles / therapeutic use
  • Ultrasonography

Substances

  • Nitroimidazoles