Tinidazole for the treatment of amoebic liver abscess

S Afr Med J. 1975 Oct 25;49(45):1879-81.

Abstract

Ten patients suffering from amoebic liver abscess were treated with tinidazole (Fasigyn) 800 mg t.d.s. for 5 days. Nine were cured, and 1 patient required further treatment with other drugs. Following this, a double-blind trial was carried out to compare a group of patients treated with tinidazole with a similar group treated with metronidazole. Each series consisted of 14 patients. In the tinidazole series 13 patients were cured and for 1 patient the result of treatment was dubious. All patients in the metronidazole series were cured, but 1 patient admitted to the trial had previously not been cured by metronidazole. It appears that tinidazole and metronidazole are equally efficaceous in the treatment of amoebic liver abscess.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Clinical Trials as Topic
  • Entamoeba histolytica
  • Feces / microbiology
  • Humans
  • Liver Abscess, Amebic / diagnosis
  • Liver Abscess, Amebic / drug therapy*
  • Liver Abscess, Amebic / microbiology
  • Metronidazole / therapeutic use
  • Nitroimidazoles / therapeutic use*
  • Tinidazole / therapeutic use*

Substances

  • Nitroimidazoles
  • Tinidazole
  • Metronidazole