In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Jason Cota; Michael Carden; John R Graybill; Laura K Najvar; David S Burgess; Nathan P Wiederhold

doi:10.1128/AAC.00538-06

In vitro pharmacodynamics of anidulafungin and caspofungin against Candida glabrata isolates, including strains with decreased caspofungin susceptibility

Antimicrob Agents Chemother. 2006 Nov;50(11):3926-8. doi: 10.1128/AAC.00538-06. Epub 2006 Aug 28.

Authors

Jason Cota¹, Michael Carden, John R Graybill, Laura K Najvar, David S Burgess, Nathan P Wiederhold

Affiliation

¹ University of Texas at Austin College of Pharmacy, UTHSCSA, Clinical Pharmacy, MSC 6220, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.

Abstract

The activities of anidulafungin and caspofungin against Candida glabrata were evaluated. MICs, 50% inhibitory concentrations (IC(50) values), and IC(90) values for anidulafungin were lower than those for caspofungin for 16 of 18 strains tested. Anidulafungin has potent in vitro activity against C. glabrata that is maintained against isolates with elevated caspofungin MICs.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anidulafungin
Antifungal Agents / pharmacology*
Candida glabrata / drug effects*
Candidiasis / microbiology
Caspofungin
Colorimetry
Dose-Response Relationship, Drug
Drug Resistance, Fungal
Echinocandins
Humans
Kinetics
Lipopeptides
Microbial Sensitivity Tests
Peptides, Cyclic / pharmacology*
Tetrazolium Salts

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Peptides, Cyclic
Tetrazolium Salts
2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-5-((phenylamino)carbonyl)-2H-tetrazolium hydroxide
Anidulafungin
Caspofungin