Candida albicans and Candida glabrata clinical isolates exhibiting reduced echinocandin susceptibility

Antimicrob Agents Chemother. 2006 Aug;50(8):2892-4. doi: 10.1128/AAC.00349-06.

Abstract

A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Amino Acid Sequence
  • Amino Acid Substitution
  • Antifungal Agents / pharmacology*
  • Candida albicans / drug effects*
  • Candida albicans / enzymology
  • Candida albicans / genetics
  • Candida albicans / isolation & purification*
  • Candida glabrata / drug effects*
  • Candida glabrata / enzymology
  • Candida glabrata / genetics
  • Candida glabrata / isolation & purification*
  • Candidiasis / microbiology
  • Conserved Sequence
  • Drug Resistance, Fungal / genetics
  • Fungal Proteins / antagonists & inhibitors
  • Fungal Proteins / genetics
  • Fungal Proteins / metabolism
  • Genes, Fungal
  • Glucosyltransferases / antagonists & inhibitors
  • Glucosyltransferases / genetics
  • Glucosyltransferases / metabolism
  • Humans
  • Microbial Sensitivity Tests / methods
  • Molecular Sequence Data
  • Peptides, Cyclic / pharmacology*
  • Sequence Homology, Amino Acid

Substances

  • Antifungal Agents
  • Fungal Proteins
  • Peptides, Cyclic
  • Glucosyltransferases
  • 1,3-beta-glucan synthase