Abstract
A recognized hotspot for mutations conferring reduced echinocandin susceptibility (RES) is residue S645 of Candida albicans Gsc1(Fks1). We report that the mutation F641Y is associated with RES in a C. albicans isolate. The analogous Fks2 residue is mutated F to V in a Candida glabrata RES isolate; the introduction of this mutation into susceptible C. glabrata confirmed its role in RES. Y641-equivalent Fks residues were identified in intrinsically RES Fusarium species and Candida guilliermondii.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Amino Acid Sequence
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Amino Acid Substitution
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Antifungal Agents / pharmacology*
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Candida albicans / drug effects*
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Candida albicans / enzymology
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Candida albicans / genetics
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Candida albicans / isolation & purification*
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Candida glabrata / drug effects*
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Candida glabrata / enzymology
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Candida glabrata / genetics
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Candida glabrata / isolation & purification*
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Candidiasis / microbiology
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Conserved Sequence
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Drug Resistance, Fungal / genetics
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Fungal Proteins / antagonists & inhibitors
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Fungal Proteins / genetics
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Fungal Proteins / metabolism
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Genes, Fungal
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Glucosyltransferases / antagonists & inhibitors
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Glucosyltransferases / genetics
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Glucosyltransferases / metabolism
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Humans
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Microbial Sensitivity Tests / methods
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Molecular Sequence Data
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Peptides, Cyclic / pharmacology*
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Sequence Homology, Amino Acid
Substances
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Antifungal Agents
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Fungal Proteins
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Peptides, Cyclic
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Glucosyltransferases
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1,3-beta-glucan synthase