Hantavirus cardiopulmonary syndrome: immune response and pathogenesis

Microbes Infect. 2006 Jul;8(8):2324-30. doi: 10.1016/j.micinf.2006.04.019. Epub 2006 Jun 2.

Abstract

Hantaviruses are emerging viruses in the Americas that cause cardiopulmonary syndrome with high lethality. The intense cellular immune response to hantavirus alters normal endothelial cell barrier functions and seems to be harmful to the host. On the other hand, the humoral immune response seems to be essential for recovery from infection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antibodies, Viral / analysis
  • Hantavirus Pulmonary Syndrome / genetics
  • Hantavirus Pulmonary Syndrome / immunology*
  • Hantavirus Pulmonary Syndrome / physiopathology
  • Hantavirus Pulmonary Syndrome / virology
  • Humans
  • Immunity, Cellular
  • Models, Biological
  • Orthohantavirus / genetics
  • Orthohantavirus / immunology
  • Viremia

Substances

  • Antibodies, Viral