Successful use of combination antifungal therapy in the treatment of coccidioides meningitis

J Natl Med Assoc. 2006 Jun;98(6):940-2.

Abstract

Coccidioidal meningitis is a highly lethal condition with a high morbidity and relapse rate caused by Coccidioides immitis. This case report highlights the difficulty in diagnosing and treating coccidioidal meningitis, and discusses a novel combination antifungal therapy (voriconazole and liposomal amphotericin B), which was used to treat this patient.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Amphotericin B / therapeutic use*
  • Antifungal Agents / therapeutic use*
  • Coccidioides / drug effects
  • Coccidioides / isolation & purification
  • Coccidioidomycosis / diagnosis
  • Coccidioidomycosis / drug therapy*
  • Diagnosis, Differential
  • Drug Therapy, Combination
  • Humans
  • Male
  • Meningitis, Fungal / diagnosis
  • Meningitis, Fungal / drug therapy*
  • Pyrimidines / therapeutic use*
  • Triazoles / therapeutic use*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Amphotericin B
  • Voriconazole