Abstract
We present here findings of a strong positive correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus (VISA). This correlation is related to cell wall thickening, suggesting that, similar to the case with vancomycin resistance in VISA, the physical barrier of a thickened cell wall may contribute to daptomycin resistance in S. aureus.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / pharmacology*
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Cell Wall / ultrastructure
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Daptomycin / pharmacology*
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Linear Models
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Microbial Sensitivity Tests
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Staphylococcal Infections / drug therapy
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / genetics*
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Vancomycin / pharmacology*
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Vancomycin Resistance / genetics*
Substances
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Anti-Bacterial Agents
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Vancomycin
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Daptomycin