A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen

Marcela Parra; Nathalie Cadieux; Thames Pickett; Veerabadran Dheenadhayalan; Michael J Brennan

doi:10.1128/IAI.74.1.786-789.2006

A PE protein expressed by Mycobacterium avium is an effective T-cell immunogen

Infect Immun. 2006 Jan;74(1):786-9. doi: 10.1128/IAI.74.1.786-789.2006.

Authors

Marcela Parra¹, Nathalie Cadieux, Thames Pickett, Veerabadran Dheenadhayalan, Michael J Brennan

Affiliation

¹ Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Bldg 29, Rm 503, HFM-431, 29 Lincoln Drive, Bethesda, MD 20892, USA.

Abstract

Infection of mice with Mycobacterium avium or immunization with a novel PE gene expressed by M. avium (MaPE) showed that a dominant T-cell immune response was elicited. Immunization with an MaPE DNA vaccine protected mice against an aerosol challenge with Mycobacterium tuberculosis, suggesting that mycobacteria express PE antigens with cross-protective T-cell epitopes.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Amino Acid Sequence
Animals
Antigens, Bacterial / immunology
Bacterial Proteins / immunology*
Electrophoresis, Agar Gel
Mice
Mice, Inbred C57BL
Molecular Sequence Data
Mycobacterium avium / immunology*
Mycobacterium tuberculosis / immunology
T-Lymphocyte Subsets / immunology*
T-Lymphocyte Subsets / microbiology*
Tuberculosis / immunology*
Tuberculosis / prevention & control
Tuberculosis / veterinary
Tuberculosis Vaccines / immunology*

Substances

Antigens, Bacterial
Bacterial Proteins
Tuberculosis Vaccines