Effect of voriconazole combined with micafungin against Candida, Aspergillus, and Scedosporium spp. and Fusarium solani

Antimicrob Agents Chemother. 2005 Dec;49(12):5157-9. doi: 10.1128/AAC.49.12.5157-5159.2005.

Abstract

Effects of voriconazole combined with micafungin against 101 isolates of Candida spp. and 100 isolates of filamentous fungi have been evaluated by in vitro checkerboard analysis. The combination was indifferent for 97% of the Candida isolates and synergistic for 64% of the filamentous fungi (79% for Aspergillus fumigatus).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects*
  • Candida / drug effects*
  • Drug Synergism
  • Drug Therapy, Combination
  • Echinocandins
  • Fusarium / drug effects*
  • Lipopeptides
  • Lipoproteins / pharmacology*
  • Micafungin
  • Microbial Sensitivity Tests
  • Peptides, Cyclic / pharmacology*
  • Pyrimidines / pharmacology*
  • Scedosporium / drug effects*
  • Triazoles / pharmacology*
  • Voriconazole

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Lipoproteins
  • Peptides, Cyclic
  • Pyrimidines
  • Triazoles
  • Voriconazole
  • Micafungin