Candida albicans endocarditis treatment with caspofungin in an HIV-infected patient--case report and review of literature

Valentina Bacak; Bojan Biocina; Boris Starcevic; Sarah Gertler; Josip Begovac

doi:10.1016/j.jinf.2005.10.003

Candida albicans endocarditis treatment with caspofungin in an HIV-infected patient--case report and review of literature

J Infect. 2006 Jul;53(1):e11-4. doi: 10.1016/j.jinf.2005.10.003. Epub 2005 Nov 7.

Authors

Valentina Bacak¹, Bojan Biocina, Boris Starcevic, Sarah Gertler, Josip Begovac

Affiliation

¹ Department of HIV/AIDS, University Hospital for Infectious Diseases, Mirogojska 8, 10000 Zagreb, Croatia.

PMID: 16274746
DOI: 10.1016/j.jinf.2005.10.003

Abstract

Caspofungin has recently been introduced for the treatment of invasive candidiasis, however, there is limited data on its use in endocarditis. We report a 22-year-old male HIV-infected patient on methadone maintenance therapy that developed right-sided Candida albicans endocarditis. Caspofungin treatment and vegetectomy, followed by fluconazole, was successful in the treatment of our patient. We also review all previous cases of Candida endocarditis treated with caspofungin.

Publication types

Case Reports
Review

MeSH terms

AIDS-Related Opportunistic Infections / drug therapy*
AIDS-Related Opportunistic Infections / microbiology
Adult
Antifungal Agents / therapeutic use*
Candida albicans / drug effects*
Candidiasis / drug therapy*
Candidiasis / microbiology
Caspofungin
Echinocandins
Endocarditis / drug therapy*
Endocarditis / microbiology
HIV Infections / complications
Humans
Lipopeptides
Male
Peptides, Cyclic / therapeutic use*
Treatment Outcome

Substances

Antifungal Agents
Echinocandins
Lipopeptides
Peptides, Cyclic
Caspofungin