Candida glabrata fungemia cured by antibiotic-lock therapy: case report and short review

J Infect. 2005 Oct;51(3):e85-7. doi: 10.1016/j.jinf.2004.08.034.

Abstract

Catheter removal is now the standard recommendation of catheter-related fungemia even when tunneled devices are used. However, in the clinical practice, this procedure is not always without risks. Antibiotic-lock technique can resolve many cases of catheter-related bacteraemia, but cure of catheter-related candidemia by this method has been attempted in very few instances, reviewed in this article. Herein, we report a case of non-complicated Candida glabrata fungemia related to a Hickman catheter used for parenteral nutrition, cured with intraluminal amphotericin B in addition to systemic therapy. This case demonstrates that 'antifungal-lock therapy' can be effectively used in selected cases of catheter-related candidemia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Amphotericin B / administration & dosage
  • Amphotericin B / therapeutic use
  • Antifungal Agents / administration & dosage*
  • Antifungal Agents / therapeutic use
  • Candida glabrata / drug effects*
  • Candida glabrata / isolation & purification
  • Candidiasis / drug therapy
  • Candidiasis / microbiology
  • Catheterization, Central Venous / adverse effects*
  • Catheterization, Central Venous / instrumentation
  • Catheters, Indwelling / microbiology*
  • Equipment Contamination / prevention & control
  • Female
  • Fluconazole / administration & dosage
  • Fluconazole / therapeutic use
  • Fungemia / drug therapy*
  • Fungemia / microbiology
  • Humans
  • Parenteral Nutrition

Substances

  • Antifungal Agents
  • Amphotericin B
  • Fluconazole