Abstract
Eight patients with AIDS were treated orally with 800 mg of fluconazole daily for cryptococcal meningitis for a mean duration of 4.5 months. Previous antifungal treatment had failed for all of the patients. No major toxicity was observed. Three patients died from cryptococcal infection. High-dose fluconazole may be effective salvage therapy for cryptococcal meningitis.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications*
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Administration, Oral
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Adult
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Fluconazole / therapeutic use*
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Humans
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Male
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Meningitis, Cryptococcal / complications
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Meningitis, Cryptococcal / drug therapy*
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Meningitis, Cryptococcal / mortality
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Opportunistic Infections / complications*
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Opportunistic Infections / drug therapy
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Opportunistic Infections / mortality