Abstract
Phylogenetic analysis has led to the classification of hepatitis B virus into eight genotypes, designated A to H. The genotypes have differences in biological properties and show heterogeneity in their global distribution. These attributes of the genotypes may account not only for differences in the prevalence of hepatitis B virus mutants in various geographic regions, but also be responsible for differences in the clinical outcome and response to antiviral treatment in different population groups.
Publication types
-
Research Support, Non-U.S. Gov't
-
Review
MeSH terms
-
Antiviral Agents / administration & dosage*
-
Antiviral Agents / pharmacology
-
Carcinoma, Hepatocellular / virology
-
DNA, Viral / genetics*
-
Disease Progression
-
Genetic Heterogeneity*
-
Genotype
-
Hepatitis B / drug therapy
-
Hepatitis B / genetics*
-
Hepatitis B / pathology
-
Hepatitis B virus / drug effects
-
Hepatitis B virus / genetics*
-
Hepatitis B virus / pathogenicity
-
Humans
-
Mutation
-
Prevalence
-
Prognosis
Substances
-
Antiviral Agents
-
DNA, Viral