In vitro synergy testing of anidulafungin with itraconazole, voriconazole, and amphotericin B against Aspergillus spp. and Fusarium spp

Antimicrob Agents Chemother. 2005 Aug;49(8):3572-4. doi: 10.1128/AAC.49.8.3572-3574.2005.

Abstract

The in vitro interactions of anidulafungin with itraconazole, voriconazole, and amphotericin B were evaluated by using the checkerboard method. For Aspergillus spp., anidulafungin with amphotericin B showed indifference for 16/26 isolates, while anidulafungin with either azole showed a synergy trend for 18/26 isolates. All drug combinations showed indifference for 7/7 Fusarium sp. isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Anidulafungin
  • Antifungal Agents / pharmacology*
  • Aspergillus / classification
  • Aspergillus / drug effects*
  • Drug Synergism
  • Echinocandins
  • Fusarium / classification
  • Fusarium / drug effects*
  • Humans
  • Itraconazole / pharmacology
  • Microbial Sensitivity Tests / methods
  • Microbial Sensitivity Tests / standards
  • Peptides, Cyclic / pharmacology*
  • Pyrimidines / pharmacology
  • Triazoles / pharmacology
  • Voriconazole

Substances

  • Antifungal Agents
  • Echinocandins
  • Peptides, Cyclic
  • Pyrimidines
  • Triazoles
  • Itraconazole
  • Amphotericin B
  • Anidulafungin
  • Voriconazole