Candida prosthetic valve endocarditis cured by caspofungin therapy without valve replacement

Clin Infect Dis. 2005 May 1;40(9):e72-4. doi: 10.1086/429322. Epub 2005 Mar 23.

Abstract

A 64-year-old woman with a mechanical mitral valve prosthesis developed late-onset Candida endocarditis. Blood cultures grew Candida glabrata and Candida krusei. Transesophageal echocardiography demonstrated vegetations on the valve. The patient was not medically fit for valve replacement, but her condition was successfully treated with 6 weeks of intravenous caspofungin therapy.

Publication types

  • Case Reports

MeSH terms

  • Antifungal Agents / therapeutic use*
  • Candidiasis / drug therapy*
  • Caspofungin
  • Echinocandins
  • Endocarditis / drug therapy*
  • Endocarditis / microbiology*
  • Female
  • Heart Valve Prosthesis*
  • Humans
  • Lipopeptides
  • Middle Aged
  • Peptides, Cyclic / therapeutic use*

Substances

  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Peptides, Cyclic
  • Caspofungin