Investigation of a nosocomial outbreak of extended-spectrum beta-lactamase VEB-1-producing isolates of Acinetobacter baumannii in a hospital setting

J Hosp Infect. 2005 May;60(1):14-8. doi: 10.1016/j.jhin.2004.07.027.

Abstract

A nosocomial outbreak of epidemiologically related VEB-1 extended-spectrum beta-lactamase-producing isolates of Acinetobacter baumannii occurred in 33 patients in an intensive care unit. A case-control study identified previous treatment with third-generation cephalosporins as the only risk factor for A. baumannii acquisition. Rationale for antibiotic use should be strengthened.

MeSH terms

  • Acinetobacter Infections / epidemiology*
  • Acinetobacter Infections / microbiology
  • Acinetobacter Infections / prevention & control
  • Acinetobacter baumannii* / enzymology
  • Acinetobacter baumannii* / genetics
  • Acinetobacter baumannii* / isolation & purification
  • Aged
  • Anti-Bacterial Agents / adverse effects
  • Bacterial Typing Techniques
  • Case-Control Studies
  • Cephalosporins / adverse effects
  • Cluster Analysis
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Cross Infection / prevention & control
  • DNA, Bacterial / analysis
  • DNA, Bacterial / genetics
  • Disease Outbreaks / prevention & control
  • Disease Outbreaks / statistics & numerical data*
  • Drug Utilization
  • Electrophoresis, Gel, Pulsed-Field
  • Escherichia coli Proteins
  • Female
  • France / epidemiology
  • Humans
  • Infection Control / methods
  • Intensive Care Units
  • Logistic Models
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Multivariate Analysis
  • Phylogeny
  • Polymerase Chain Reaction
  • Risk Factors
  • Time Factors
  • beta-Lactam Resistance / genetics
  • beta-Lactamases* / biosynthesis

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • DNA, Bacterial
  • Escherichia coli Proteins
  • beta-lactamase VEB-1, E coli
  • beta-Lactamases