Persistent bacteremia due to methicillin-resistant Staphylococcus aureus infection is associated with agr dysfunction and low-level in vitro resistance to thrombin-induced platelet microbicidal protein

J Infect Dis. 2004 Sep 15;190(6):1140-9. doi: 10.1086/423145. Epub 2004 Aug 12.

Abstract

Background: The causes of persistent bacteremia (PB) due to methicillin-resistant Staphylococcus aureus (MRSA) are poorly understood. This investigation examined potential associations between PB with key clinical features and several in vitro bacterial genotypic and phenotypic characteristics, in isolates from 1 institution.

Methods: Pulsed-field gel electrophoresis (PFGE) relatedness, thrombin-induced platelet microbicidal protein (tPMP)-susceptibility phenotype, accessory gene regulator (agr) genotype and functionality (via delta-lysin production), and autolysis phenotypes were assessed in MRSA isolates from the bloodstream of 21 prospectively identified patients with PB (blood cultures positive after > or =7 days of therapy) and of 18 patients with resolving bacteremia (RB) (sterile blood cultures within the first 2-4 days of therapy) due to MRSA.

Results: The 2 groups had comparable baseline characteristics but differed in their clinical courses (e.g., endocarditis was more frequent in patients with PB than in those with RB [43% vs. 0%, respectively; P=.0016]); isolates from patients with PB exhibited higher rates of (1) survival in vitro after exposure to tPMP (22.4+/-14.8% vs. 11.6+/-6.5%, respectively; P=.005); (2) defective delta-lysin production (71.4% vs. 38.9%, respectively; P=.057); (3) non-agr genotype II profile (100% vs. 77.8%, respectively; P=.037); and (4) overrepresentation of a specific PFGE genotype (85.7% vs. 44.4%, respectively; P=.015).

Conclusions: Isolates from patients with PB differed from those in patients with RB, in several in vitro characteristics. Further studies will be necessary to define how these factors might affect clinical outcome.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-Bacterial Agents / immunology
  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / immunology
  • Bacteremia / microbiology*
  • Bacterial Proteins / genetics
  • Bacterial Proteins / physiology*
  • Bacterial Typing Techniques
  • Chemokines / immunology
  • Chemokines / pharmacology*
  • DNA Fingerprinting
  • DNA, Bacterial / analysis
  • DNA, Bacterial / isolation & purification
  • DNA, Bacterial / metabolism
  • Deoxyribonucleases, Type II Site-Specific / metabolism
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Genotype
  • Hemolysin Proteins / metabolism
  • Humans
  • Male
  • Methicillin Resistance
  • Phenotype
  • Polymorphism, Restriction Fragment Length
  • Staphylococcal Infections / immunology
  • Staphylococcal Infections / microbiology*
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / genetics*
  • Staphylococcus aureus / isolation & purification
  • Trans-Activators / genetics
  • Trans-Activators / physiology*
  • beta-Thromboglobulin

Substances

  • Agr protein, Staphylococcus aureus
  • Anti-Bacterial Agents
  • Bacterial Proteins
  • Chemokines
  • DNA, Bacterial
  • Hemolysin Proteins
  • PPBP protein, human
  • Trans-Activators
  • beta-Thromboglobulin
  • CCCGGG-specific type II deoxyribonucleases
  • Deoxyribonucleases, Type II Site-Specific