Abstract
A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-gamma and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-gamma, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.
MeSH terms
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Antiviral Agents / therapeutic use*
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Child
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Diabetes Mellitus, Type 1 / complications
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Drug Resistance, Fungal
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Drug Therapy, Combination
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Granulocyte Colony-Stimulating Factor / administration & dosage
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Granulocyte Colony-Stimulating Factor / therapeutic use
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Granulocyte-Macrophage Colony-Stimulating Factor / administration & dosage
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Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
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HIV Infections / complications
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Humans
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Immunocompromised Host
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Interferon-gamma / therapeutic use*
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Male
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Mucor / pathogenicity
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Mucormycosis / drug therapy*
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Mucormycosis / pathology
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Mycetoma / drug therapy*
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Mycetoma / pathology
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Scedosporium / pathogenicity
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Treatment Outcome
Substances
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Antiviral Agents
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Granulocyte Colony-Stimulating Factor
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Interferon-gamma
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Granulocyte-Macrophage Colony-Stimulating Factor