Abstract
Immunocompetent (nu/+) and athymic (nu/nu) BALB/c mice were infected intravenously with Wangiella dermatitidis and treated with posaconazole. Posaconazole reduced the counts in tissues and prolonged survival. Of particular interest, posaconazole reduced the counts of this neurotropic pathogen in the brain.
MeSH terms
-
Animals
-
Antifungal Agents / therapeutic use*
-
Brain / microbiology
-
Colony Count, Microbial
-
Exophiala*
-
Immunocompromised Host
-
Mice
-
Mice, Inbred BALB C
-
Mice, Nude
-
Mycoses / drug therapy*
-
Mycoses / microbiology
-
Survival Analysis
-
Triazoles / therapeutic use*
Substances
-
Antifungal Agents
-
Triazoles
-
posaconazole