Abstract
A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed. In a murine model, caspofungin was effective against two early isolates for which the MICs of caspofungin were low, but it was less effective against a late isolate for which the MIC of caspofungin was greater. We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs.
MeSH terms
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Acquired Immunodeficiency Syndrome / complications
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Adult
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Animals
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Antifungal Agents / pharmacology*
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Antifungal Agents / therapeutic use*
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Candida albicans / drug effects*
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Candidiasis / drug therapy*
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Candidiasis / microbiology
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Caspofungin
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Drug Resistance, Fungal
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Echinocandins
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Esophagitis / drug therapy*
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Esophagitis / microbiology
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Humans
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Lipopeptides
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Male
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Mice
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Mice, Inbred ICR
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Microbial Sensitivity Tests
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Peptides / pharmacology*
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Peptides / therapeutic use*
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Peptides, Cyclic*
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Treatment Failure
Substances
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides
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Peptides, Cyclic
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Caspofungin