Subcutaneous black fungus (phaeohyphomycosis) infection in renal transplant recipients:three cases

Transplantation. 2004 Jan 15;77(1):140-2. doi: 10.1097/01.TP.0000107287.70512.E7.

Abstract

We describe three cases of subcutaneous phaeohyphomycosis developing in the lower limbs of renal transplant recipients shortly after transplantation. Each case presented with dark-colored nodules that subsequently ulcerated. Histopathologic examination revealed dematiaceous fungal hyphae with a surrounding granulomatous reaction. The fungi were subsequently identified as Alternaria alternatum in two cases and Phialophora richardsiae in one case. In one case, the lesions resolved during a prolonged (6-month) course of itraconazole without the requirement for surgical excision. In the other two cases, combined medical and surgical treatment resulted in cure. A review of the literature on phaeohyphomycosis is presented.

Publication types

  • Review

MeSH terms

  • Aged
  • Alternaria*
  • Amphotericin B / therapeutic use
  • Antifungal Agents / therapeutic use
  • Dermatomycoses / drug therapy
  • Dermatomycoses / etiology*
  • Dermatomycoses / pathology
  • Dermatomycoses / surgery
  • Drug Therapy, Combination
  • Female
  • Humans
  • Itraconazole / therapeutic use
  • Kidney Transplantation / adverse effects*
  • Male
  • Middle Aged
  • Phialophora*

Substances

  • Antifungal Agents
  • Itraconazole
  • Amphotericin B