DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones

C M Bébéar; H Renaudin; A Charron; M Clerc; S Pereyre; C Bébéar

doi:10.1128/AAC.47.10.3323-3325.2003

DNA gyrase and topoisomerase IV mutations in clinical isolates of Ureaplasma spp. and Mycoplasma hominis resistant to fluoroquinolones

Antimicrob Agents Chemother. 2003 Oct;47(10):3323-5. doi: 10.1128/AAC.47.10.3323-3325.2003.

Authors

C M Bébéar¹, H Renaudin, A Charron, M Clerc, S Pereyre, C Bébéar

Affiliation

¹ Laboratoire de Bactériologie, Université Victor Segalen Bordeaux 2, 33076 Bordeaux, France. cecile.bebear@u-bordeaux2.fr

Abstract

Twelve clinical isolates of Ureaplasma spp. and one isolate of Mycoplasma hominis were examined for resistance to fluoroquinolones. Previously described mutations at positions 83 and 95 in GyrA (Escherichia coli numbering) and positions 80 and 87 in ParC were found. Unusual alterations were described at positions ParC 123 and 134.

MeSH terms

Adolescent
Adult
Amino Acid Substitution
DNA Gyrase / genetics*
DNA Topoisomerase IV / genetics*
Drug Resistance, Bacterial / genetics*
Female
Fluoroquinolones / pharmacology*
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Mutation*
Mycoplasma hominis / drug effects
Mycoplasma hominis / enzymology
Mycoplasma hominis / genetics*
Ureaplasma / drug effects
Ureaplasma / enzymology
Ureaplasma / genetics*

Substances

Fluoroquinolones
DNA Topoisomerase IV
DNA Gyrase