Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women

Oksana Babula; Gunta Lazdane; Juta Kroica; William J Ledger; Steven S Witkin

doi:10.1086/377234

Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women

Clin Infect Dis. 2003 Sep 1;37(5):733-7. doi: 10.1086/377234. Epub 2003 Aug 13.

Authors

Oksana Babula¹, Gunta Lazdane, Juta Kroica, William J Ledger, Steven S Witkin

Affiliation

¹ Department of Obstetric and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA.

PMID: 12942410
DOI: 10.1086/377234

Abstract

Vaginal concentrations of mannose-binding lectin (MBL) and possession of a polymorphism in codon 54 of the MBL gene were determined in 42 women with recurrent vulvovaginal candidiasis (RVVC) and 43 control subjects. Reduced vaginal MBL levels and an increased occurrence of the polymorphism were present in women with RVVC.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Candida albicans / drug effects
Candida albicans / isolation & purification
Candidiasis, Vulvovaginal / diagnosis*
Candidiasis, Vulvovaginal / genetics
Candidiasis, Vulvovaginal / metabolism*
Codon / genetics
Female
Genetic Predisposition to Disease / genetics
Humans
Latvia / epidemiology
Mannose-Binding Lectin / genetics*
Mannose-Binding Lectin / metabolism*
Polymorphism, Genetic / genetics*
Recurrence

Substances

Codon
Mannose-Binding Lectin