Voriconazole concentrations in the cerebrospinal fluid and brain tissue of guinea pigs and immunocompromised patients

Clin Infect Dis. 2003 Sep 1;37(5):728-32. doi: 10.1086/377131. Epub 2003 Aug 7.

Abstract

We characterized voriconazole concentrations in the cerebrospinal fluid (CSF) of immunocompetent guinea pigs and patients with invasive fungal infections. In animals, after receipt of oral doses of 4 or 10 mg/kg every 8 h, the mean ratios of CSF to plasma total and free drug concentration were 0.68 and 1.3, respectively. In humans, 1-10 h after receipt of voriconazole, the CSF concentrations ranged from 0.08 to 3.93 microg/mL, and the ratio of CSF to plasma concentration ranged from 0.22 to 1.0 (median, 0.46).

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adolescent
  • Adult
  • Animals
  • Antifungal Agents / administration & dosage
  • Antifungal Agents / blood
  • Antifungal Agents / cerebrospinal fluid
  • Antifungal Agents / metabolism
  • Brain / metabolism*
  • Brain / pathology*
  • Brain Chemistry
  • Child
  • Child, Preschool
  • Drug Administration Schedule
  • Female
  • Guinea Pigs
  • Humans
  • Immunocompromised Host*
  • Male
  • Middle Aged
  • Mycoses / drug therapy*
  • Pyrimidines / administration & dosage
  • Pyrimidines / blood
  • Pyrimidines / cerebrospinal fluid*
  • Triazoles / administration & dosage
  • Triazoles / blood
  • Triazoles / cerebrospinal fluid*
  • Voriconazole

Substances

  • Antifungal Agents
  • Pyrimidines
  • Triazoles
  • Voriconazole