Addition of caspofungin to fluconazole does not improve outcome in murine candidiasis

Antimicrob Agents Chemother. 2003 Jul;47(7):2373-5. doi: 10.1128/AAC.47.7.2373-2375.2003.

Abstract

Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / pharmacology*
  • Candidiasis / drug therapy*
  • Caspofungin
  • Drug Therapy, Combination
  • Echinocandins
  • Fluconazole / pharmacology*
  • Lipopeptides
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred ICR
  • Peptides*
  • Peptides, Cyclic*

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Echinocandins
  • Lipopeptides
  • Peptides
  • Peptides, Cyclic
  • Fluconazole
  • Caspofungin