Abstract
Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology*
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Antifungal Agents / pharmacology*
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Candidiasis / drug therapy*
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Caspofungin
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Drug Therapy, Combination
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Echinocandins
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Fluconazole / pharmacology*
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Lipopeptides
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Mice
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Mice, Inbred BALB C
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Mice, Inbred ICR
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Peptides*
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Peptides, Cyclic*
Substances
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Anti-Bacterial Agents
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Antifungal Agents
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Echinocandins
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Lipopeptides
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Peptides
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Peptides, Cyclic
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Fluconazole
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Caspofungin