Ten patients with granuloma inguinale (venereum), were studied and treated in the "Institute of Dermatology" of Guatemala city, and the high incidence of this venereal desease is noted by the author. Also, there is the detailed description of two cases which were complicated with dissemination of the granuloma inguinate to distant organs of the body; one shows knee joint lesions and the other the invasion of the lungs. 9 cases were successfully treated with a semisynthetic Tetracycline drug alone and one patient, received the combined treatment of Tetracycline and Streptomycine, with spectacularly good results.