Fluconazole therapy for Candida albicans urinary tract infections in infants

Pediatr Nephrol. 2002 Jul;17(7):550-3. doi: 10.1007/s00467-002-0861-y. Epub 2002 Jun 21.

Abstract

Candiduria is rare in newborns and infants, occurring most often in patients with risk factors. When associated with a candidal bezoar in the urinary tract, candiduria is usually treated by systemic amphotericin B and flucytosine plus local irrigation with amphotericin B. We describe the successful treatment of five newborns with a urinary tract infection, on major urological malformations, due to Candida albicans (including three with a candidal bezoar) by fluconazole alone. No adverse effects or recurrences were observed. Fluconazole therapy permits early discharge from the hospital and seems suitable for infants and newborns with a C. albicans urinary tract infection.

Publication types

  • Clinical Trial

MeSH terms

  • Antifungal Agents / blood
  • Antifungal Agents / therapeutic use*
  • Bezoars / drug therapy
  • Candidiasis / drug therapy*
  • Fluconazole / blood
  • Fluconazole / therapeutic use*
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Treatment Outcome
  • Urinary Tract Infections / drug therapy*

Substances

  • Antifungal Agents
  • Fluconazole