Treatment of Scedosporium apiospermum brain abscesses with posaconazole

Ingo K Mellinghoff; Drew J Winston; Geoffrey Mukwaya; Gary J Schiller

doi:10.1086/340522

Treatment of Scedosporium apiospermum brain abscesses with posaconazole

Clin Infect Dis. 2002 Jun 15;34(12):1648-50. doi: 10.1086/340522. Epub 2002 May 16.

Authors

Ingo K Mellinghoff¹, Drew J Winston, Geoffrey Mukwaya, Gary J Schiller

Affiliation

¹ Division of Hematology-Oncology, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA, 90095, USA.

PMID: 12032903
DOI: 10.1086/340522

Abstract

A 41-year-old man with acute lymphoblastic leukemia developed multiple Scedosporium apiospermum brain abscesses. The infection progressed despite neurosurgical drainage and treatment with itraconazole, amphotericin B, and ketoconazole, but the brain abscesses completely resolved after treatment with posaconazole alone.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Antifungal Agents / therapeutic use*
Brain Abscess / drug therapy*
Brain Abscess / microbiology
Humans
Male
Mycetoma / drug therapy*
Scedosporium* / drug effects
Treatment Outcome
Triazoles / therapeutic use*

Substances

Antifungal Agents
Triazoles
posaconazole