Cerebrospinal fluid penetration and pharmacokinetic/pharmacodynamic parameters of intravenously administered colistin in a case of multidrug-resistant Acinetobacter baumannii meningitis

Eur J Clin Microbiol Infect Dis. 2002 Mar;21(3):212-4. doi: 10.1007/s10096-001-0680-2. Epub 2002 Mar 19.

Abstract

Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations.

Publication types

  • Case Reports

MeSH terms

  • Acinetobacter / drug effects*
  • Acinetobacter Infections / drug therapy
  • Acinetobacter Infections / microbiology
  • Adolescent
  • Anti-Bacterial Agents / blood
  • Anti-Bacterial Agents / cerebrospinal fluid
  • Anti-Bacterial Agents / pharmacokinetics
  • Anti-Bacterial Agents / therapeutic use
  • Colistin / blood
  • Colistin / cerebrospinal fluid*
  • Colistin / pharmacokinetics*
  • Colistin / therapeutic use
  • Drug Resistance, Multiple*
  • Humans
  • Injections, Intravenous
  • Male
  • Meningitis, Bacterial / drug therapy*
  • Meningitis, Bacterial / microbiology*
  • Microbial Sensitivity Tests

Substances

  • Anti-Bacterial Agents
  • Colistin