Abstract
Described here is a case of meningitis caused by multidrug-resistant Acinetobacter baumannii susceptible only to colistin, which was treated successfully with intravenous colistin sulfomethate sodium (5 mg/kg/day). The levels of colistin in serum and cerebrospinal fluid and the pharmacokinetic/pharmacodynamic parameters of colistin were determined. In this case, intravenously administered colistin penetrated cerebrospinal fluid (25% of serum levels) at levels sustaining bactericidal concentrations.
MeSH terms
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Acinetobacter / drug effects*
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Acinetobacter Infections / drug therapy
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Acinetobacter Infections / microbiology
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Adolescent
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Anti-Bacterial Agents / blood
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Anti-Bacterial Agents / cerebrospinal fluid
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Anti-Bacterial Agents / pharmacokinetics
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Anti-Bacterial Agents / therapeutic use
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Colistin / blood
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Colistin / cerebrospinal fluid*
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Colistin / pharmacokinetics*
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Colistin / therapeutic use
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Drug Resistance, Multiple*
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Humans
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Injections, Intravenous
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Male
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Meningitis, Bacterial / drug therapy*
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Meningitis, Bacterial / microbiology*
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Microbial Sensitivity Tests
Substances
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Anti-Bacterial Agents
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Colistin