Synergistic activities of macrolide antibiotics against Pseudomonas aeruginosa, Burkholderia cepacia, Stenotrophomonas maltophilia, and Alcaligenes xylosoxidans isolated from patients with cystic fibrosis

Antimicrob Agents Chemother. 2002 Apr;46(4):1105-7. doi: 10.1128/AAC.46.4.1105-1107.2002.

Abstract

Azithromycin and clarithromycin were paired with other antibiotics to test synergistic activity against 300 multidrug-resistant pathogens isolated from cystic fibrosis (CF) patients. Clarithromycin-tobramycin was most active against Pseudomonas aeruginosa and inhibited 58% of strains. Azithromycin-trimethoprim-sulfamethoxazole, azithromycin-ceftazidime, and azithromycin-doxycycline or azithromycin-trimethoprim-sulfamethoxazole inhibited 40, 20, and 22% of Stenotrophomonas maltophilia, Burkholderia cepacia complex, and Achromobacter (Alcaligenes) xylosoxidans strains, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcaligenes / drug effects*
  • Anti-Bacterial Agents / pharmacology*
  • Burkholderia cepacia / drug effects*
  • Cystic Fibrosis / microbiology*
  • Drug Resistance, Microbial
  • Drug Resistance, Multiple
  • Drug Synergism
  • Humans
  • Macrolides
  • Microbial Sensitivity Tests
  • Pseudomonas aeruginosa / drug effects*
  • Stenotrophomonas maltophilia / drug effects*

Substances

  • Anti-Bacterial Agents
  • Macrolides