In vitro synergy of caspofungin and amphotericin B against Aspergillus and Fusarium spp

Antimicrob Agents Chemother. 2002 Jan;46(1):245-7. doi: 10.1128/AAC.46.1.245-247.2002.

Abstract

We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and FUSARIUM: Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology*
  • Anti-Bacterial Agents / pharmacology*
  • Antifungal Agents / pharmacology*
  • Aspergillus / drug effects*
  • Caspofungin
  • Drug Combinations
  • Drug Synergism
  • Echinocandins
  • Fusarium / drug effects*
  • Humans
  • Lipopeptides
  • Microbial Sensitivity Tests
  • Peptides*
  • Peptides, Cyclic*

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Drug Combinations
  • Echinocandins
  • Lipopeptides
  • Peptides
  • Peptides, Cyclic
  • Amphotericin B
  • Caspofungin