Complete nucleotide sequence of the rhesus lymphocryptovirus: genetic validation for an Epstein-Barr virus animal model

J Virol. 2002 Jan;76(1):421-6. doi: 10.1128/jvi.76.1.421-426.2002.

Abstract

We sequenced the rhesus lymphocryptovirus (LCV) genome in order to determine its genetic similarity to Epstein-Barr virus (EBV). The rhesus LCV encodes a repertoire identical to that of EBV, with 80 open reading frames, including cellular interleukin-10, bcl-2, and colony-stimulating factor 1 receptor homologues and an equivalent set of viral glycoproteins. The highly conserved rhesus LCV gene repertoire provides a unique animal model for the study of EBV pathogenesis.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Genome, Viral*
  • Lymphocryptovirus / genetics*
  • Macaca mulatta
  • Open Reading Frames
  • Sequence Homology
  • Viral Proteins / genetics

Substances

  • Viral Proteins