Development of acyclovir-resistant herpes simplex virus early during the treatment of herpes neonatorum

Pediatr Infect Dis J. 2001 Nov;20(11):1094-7. doi: 10.1097/00006454-200111000-00021.

Abstract

Genotypic analysis of herpes simplex virus (HSV) DNA extracted from clinical specimens from a case of fatal disseminated neonatal HSV demonstrated that an infant developed an acyclovir-resistant HSV containing a mutation in the HSV thymidine kinase gene during the first seven days of acyclovir therapy.

Publication types

  • Case Reports

MeSH terms

  • Acyclovir / pharmacology*
  • Acyclovir / therapeutic use
  • Antiviral Agents / pharmacology*
  • Antiviral Agents / therapeutic use
  • Autopsy
  • DNA, Viral / analysis
  • DNA, Viral / chemistry
  • Drug Resistance, Viral
  • Fatal Outcome
  • Female
  • Foscarnet / pharmacology
  • Foscarnet / therapeutic use
  • Genotype
  • Herpes Simplex / drug therapy*
  • Herpes Simplex / transmission
  • Humans
  • Immunoenzyme Techniques
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Male
  • Microbial Sensitivity Tests
  • Mutation
  • Polymerase Chain Reaction
  • Pregnancy
  • Simplexvirus / drug effects*
  • Simplexvirus / genetics
  • Simplexvirus / isolation & purification
  • Thymidine Kinase / genetics

Substances

  • Antiviral Agents
  • DNA, Viral
  • Foscarnet
  • Thymidine Kinase
  • Acyclovir