In vitro susceptibility of Coxiella burnetii to linezolid in comparison with its susceptibilities to quinolones, doxycycline, and clarithromycin

Antimicrob Agents Chemother. 2001 Nov;45(11):3276-8. doi: 10.1128/AAC.45.11.3276-3278.2001.

Abstract

The in vitro susceptibility to linezolid shown by nine Greek isolates of Coxiella burnetii derived from patients with acute Q fever was investigated. MICs of linezolid were compared with those of pefloxacin, ciprofloxacin, ofloxacin, trovafloxacin, doxycycline, and clarithromycin using the shell vial assay. MICs of linezolid and clarithromycin ranged from 2 to 4 microg/ml; those of doxycycline, trovafloxacin, and ofloxacin ranged from 1 to 2 microg/ml; those of pefloxacin ranged from 1 to 4 microg/ml; and those of ciprofloxacin ranged from 4 to 8 microg/ml. Linezolid was effective in controlling intracellular parasites in cultures of Vero cells infected by C. burnetii. No bactericidal activity by linezolid was obtained against C. burnetii at 8 microg/ml.

Publication types

  • Comparative Study

MeSH terms

  • Acetamides / pharmacology*
  • Animals
  • Anti-Bacterial Agents / pharmacology*
  • Chlorocebus aethiops
  • Clarithromycin / pharmacology*
  • Coxiella burnetii / drug effects*
  • Doxycycline / pharmacology*
  • Fluoroquinolones
  • Linezolid
  • Microbial Sensitivity Tests
  • Oxazolidinones / pharmacology*
  • Q Fever / microbiology
  • Vero Cells

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Fluoroquinolones
  • Oxazolidinones
  • Clarithromycin
  • Linezolid
  • Doxycycline