Abstract
The antibacterial activities of seven fluoroquinolones (ciprofloxacin, BAYy3118, clinafloxacin, gemifloxacin, moxifloxacin, sparfloxacin and trovafloxacin) against isogenic efflux-mediated multidrug-resistant strains of Pseudomonas aeruginosa, Stenotrophomonas maltophilia and Burkholderia cepacia, were compared. The results indicate that these fluoroquinolones are all substrates for the multidrug efflux systems of these organisms. Clinafloxacin was found generally to be the most active agent against multidrug-resistant strains.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Infective Agents / metabolism
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Anti-Infective Agents / pharmacology*
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Biological Transport
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Burkholderia cepacia / drug effects*
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Burkholderia cepacia / genetics
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Drug Resistance, Multiple, Bacterial / genetics
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Fluoroquinolones
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Humans
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Microbial Sensitivity Tests
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Multidrug Resistance-Associated Proteins / genetics
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Multidrug Resistance-Associated Proteins / metabolism*
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Mutation
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Pseudomonas aeruginosa / drug effects*
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Pseudomonas aeruginosa / genetics
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Stenotrophomonas maltophilia / drug effects*
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Stenotrophomonas maltophilia / genetics
Substances
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Anti-Infective Agents
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Fluoroquinolones
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Multidrug Resistance-Associated Proteins