In vitro studies of the efficacy of antimicrobials against fungi

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2001 Jun;91(6):663-70. doi: 10.1067/moe.2001.113550.

Abstract

Objective: The purpose of this study was to compare the efficacy of Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses and a 0.2% chlorhexidine digluconate solution against known pathogenic fungi.

Study design: Standardized methods were used to compare the antimicrobial efficacy of the above agents versus representative fungal species. Minimum inhibitory concentration-minimum fungicidal concentrations in macrobroth dilutions, suspension kill-time, and effectiveness against an artificial biofilm-attached population were studied.

Results: All antimicrobials tested were effective against the fungal species under investigation at the concentration available commercially. Listerine Antiseptic showed a greater efficacy against attached artificial biofilm populations than the other antimicrobials tested.

Conclusions: Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses show promise as a means to control the pathogenic fungal species under investigation and may have applications to reduce oral colonization.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Infective Agents, Local / pharmacology*
  • Biofilms / drug effects
  • Candida / classification
  • Candida / drug effects
  • Candida albicans / drug effects
  • Chlorhexidine / analogs & derivatives*
  • Chlorhexidine / pharmacology
  • Drug Combinations
  • Drug Resistance, Microbial
  • Fungi / drug effects*
  • Fungi / pathogenicity
  • Humans
  • Microbial Sensitivity Tests
  • Mouth / microbiology
  • Mouthwashes / pharmacology*
  • Saccharomyces cerevisiae / drug effects
  • Salicylates / pharmacology
  • Spores / drug effects
  • Statistics as Topic
  • Terpenes / pharmacology
  • Time Factors

Substances

  • Anti-Infective Agents, Local
  • Drug Combinations
  • Mouthwashes
  • Salicylates
  • Terpenes
  • Listerine
  • chlorhexidine gluconate
  • Chlorhexidine