Successful treatment of recurrent vulvar intraepithelial neoplasia resistant to interferon and isotretinoin with cidofovir

J Med Virol. 2001 Jun;64(2):195-8. doi: 10.1002/jmv.1036.

Abstract

Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43-year-old woman with a 20-year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia.

Publication types

  • Case Reports

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Adult
  • Antineoplastic Agents / therapeutic use*
  • Carcinoma in Situ / drug therapy*
  • Cidofovir
  • Cytosine / analogs & derivatives
  • Cytosine / therapeutic use*
  • Drug Resistance, Multiple
  • Female
  • Humans
  • Injections, Subcutaneous
  • Interferons / therapeutic use
  • Isotretinoin / therapeutic use
  • Neoplasm Recurrence, Local / prevention & control*
  • Organophosphonates*
  • Organophosphorus Compounds / therapeutic use*
  • Uterine Cervical Dysplasia / drug therapy
  • Vulvar Neoplasms / drug therapy*

Substances

  • Antineoplastic Agents
  • Organophosphonates
  • Organophosphorus Compounds
  • Cytosine
  • Interferons
  • Isotretinoin
  • Cidofovir