In vitro activity of four fluoroquinolones against Mycobacterium tuberculosis

Int J Antimicrob Agents. 2001 Mar;17(3):229-31. doi: 10.1016/s0924-8579(00)00337-x.

Abstract

The in vitro activity of ciprofloxacin, ofloxacin, levofloxacin and moxifloxacin against strains of Mycobacterium tuberculosis was studied. Moxifloxacin and levofloxacin showed the greatest activity having an MIC(90) of 1 mg/l. The MIC(90) for ofloxacin was 2 mg/l and for ciprofloxacin 4 mg/l. Further studies should be made to determine the role played by these compounds in the treatment of tuberculosis.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Antitubercular Agents / pharmacology*
  • Aza Compounds*
  • Ciprofloxacin / pharmacology
  • Dose-Response Relationship, Drug
  • Fluoroquinolones*
  • Humans
  • Levofloxacin
  • Microbial Sensitivity Tests
  • Moxifloxacin
  • Mycobacterium tuberculosis / drug effects*
  • Ofloxacin / pharmacology
  • Quinolines*
  • Spain

Substances

  • Anti-Infective Agents
  • Antitubercular Agents
  • Aza Compounds
  • Fluoroquinolones
  • Quinolines
  • Ciprofloxacin
  • Levofloxacin
  • Ofloxacin
  • Moxifloxacin